Clinical trials began to show the efficacy and safety of vaccines, such as the mRNA-1273 vaccine (Moderna) ( 5), the BNT162b2 vaccine (Pfizer-BioNTech), and the Gam-COVID-Vac (Gamaleya's Sputnik V) ( 6). Fortunately, Coronavirus Disease-19 (COVID-19) vaccines emerged in record time.
The health services collapsed, and the loss of life was alarming in the absence of a specific treatment. The number of people infected was rapidly reached stunning figures given its high transmissibility. Continuous studies are necessary to acknowledge more post-vaccine symptoms in different populations.īy January 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that originated in Wuhan, China had already spread to Europe and by March 2020, it had already spread to the whole world ( 1– 4). At dose 2, mRNA-1273 was the vaccine with the highest rate of side effects (88%) and the only vaccine associated to greater extension (adjusted OR 2.88, 95% CI 1.59, 5.21) and severity of symptoms (adjusted OR 3.14, 95% CI 1.82, 5.43). Young age (<50 years), female sex, comorbidity, and history of allergies were associated with greater extension and severity, independent of the type of vaccine and potential confounders. Both were associated to greater extension (adjusted OR 2.53, 95% CI 2.16, 2.96 and adjusted OR 2.41, 95% CI 1.76, 3.29, respectively) and severity of side effects (adjusted OR 4.32, 95% CI 3.73, 5.00 and adjusted OR 3.00, 95% CI 2.28, 3.94, respectively). At dose 1, ChAdOx1 was the vaccine with the highest rate of at least one side effect (85%) followed by Gam-COVID-Vac (80%). Prevalence of at least one side effect varied between vaccines and by a number of doses. Descriptive and stepwise multivariate logistic ordinal regression analyses were used to calculate odds ratio (OR) and 95% CI for each outcome adjusted by potential confounders. Then, a severity index was constructed based on responses. We asked about the need to take medicine, stop activities/miss work, or seek medical attention. Side effect extension was classified as local, systemic, or both. We questioned about the type of vaccine and symptoms based on short-term side effects reported in the literature. The survey link was distributed via multiple social media platforms. The first inclusion criterion was to receive a COVID-19 vaccine and the second, being at least 18 years old. This was a cross-sectional study carried out online between August 12 and Septemin Mexico. We also evaluated the association of type of vaccine, sex, age, comorbidity, and history of allergies to the extent and severity of side effects. We compared the extension and severity of self-reported side effects of seven COVID-19 vaccines in the Mexican population. 64, Mexican Institute of Social Security, Monterrey, MexicoĪ few studies examined the comparative side effects of Coronavirus Disease-19 (COVID-19) vaccines. 5School of Biological Sciences, Autonomous University of Nuevo Leon, Monterrey, Mexico.4School of Public Health and Nutrition, Autonomous University of Nuevo Leon, Monterrey, Mexico.3Epidemiologic and Health Services Research Unit, Mexican Institute of Social Security, Monterrey, Mexico.2Health Sciences Division, Center for Molecular Diagnosis and Personalized Medicine, Universidad de Monterrey, Monterrey, Mexico.1Department of Molecular Biology, Northeast Biomedical Research Center, Mexican Institute of Social Security, Monterrey, Mexico.María Elena Camacho Moll 1,2 *, Ana María Salinas Martínez 3,4 *, Benjamín Tovar Cisneros 5, Juan Ignacio García Onofre 6, Gloria Navarrete Floriano 6 and Mario Bermúdez de León 1
0 kommentar(er)
